A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities
Tekijät: Skálová Alena, Agaimy Abbas, Bradova Martina, Poorten Vincent Vander, Hanna Ehab, Guntinas-Lichius Orlando, Franchi Alessandro, Hellquist Henrik, Simpson Roderick H. W., Lopéz Fernando, Nuyts Sandra, Chiesa-Estomba Carlos, Ng Sweet Ping, Homma Akihiro, Teng Yong, Leivo Ilmo, Ferlito Alfio
Kustantaja: Springer Nature
Julkaisuvuosi: 2024
Journal: Virchows Archiv
Tietokannassa oleva lehden nimi: Virchows Archiv : an international journal of pathology
Lehden akronyymi: Virchows Arch
ISSN: 0945-6317
eISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-024-03775-y
Verkko-osoite: https://link.springer.com/article/10.1007/s00428-024-03775-y
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387372109
Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
