Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities - UTU Tutkimustietojärjestelmä

A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities

Tekijät: Skálová Alena, Agaimy Abbas, Bradova Martina, Poorten Vincent Vander, Hanna Ehab, Guntinas-Lichius Orlando, Franchi Alessandro, Hellquist Henrik, Simpson Roderick H. W., Lopéz Fernando, Nuyts Sandra, Chiesa-Estomba Carlos, Ng Sweet Ping, Homma Akihiro, Teng Yong, Leivo Ilmo, Ferlito Alfio

Kustantaja: Springer Nature

Julkaisuvuosi: 2024

Journal: Virchows Archiv

Tietokannassa oleva lehden nimi: Virchows Archiv : an international journal of pathology

Lehden akronyymi: Virchows Arch

Vuosikerta: 484

Numero: 6

Aloitussivu: 885

Lopetussivu: 900

ISSN: 0945-6317

eISSN: 1432-2307

DOI: https://doi.org/10.1007/s00428-024-03775-y

Verkko-osoite: https://link.springer.com/article/10.1007/s00428-024-03775-y

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387372109

Tiivistelmä

Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

s00428-024-03775-y.pdf

Julkaisussa olevat rahoitustiedot:
Open access publishing supported by the National Technical Library in Prague. This study was supported by a study grant from the Cooperation Program, research area SURG (Alena Skálová, Martina Bradová), the project National Institute for Cancer Research—NICR (Programme EXCELES, ID project no. LX22NPO5102)—funded by the European Union—Next Generation EU (Alena Skálová, Martina Bradová), the Turku University Hospital Fund, the Maritza and Reino Salonen Foundation, and the Finnish Cancer Society, Finland (Ilmo Leivo).