Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities - UTU Research Portal

A2 Refereed review article in a scientific journal

Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities

Authors: Skálová Alena, Agaimy Abbas, Bradova Martina, Poorten Vincent Vander, Hanna Ehab, Guntinas-Lichius Orlando, Franchi Alessandro, Hellquist Henrik, Simpson Roderick H. W., Lopéz Fernando, Nuyts Sandra, Chiesa-Estomba Carlos, Ng Sweet Ping, Homma Akihiro, Teng Yong, Leivo Ilmo, Ferlito Alfio

Publisher: Springer Nature

Publication year: 2024

Journal: Virchows Archiv

Journal name in source: Virchows Archiv : an international journal of pathology

Journal acronym: Virchows Arch

Volume: 484

Issue: 6

First page : 885

Last page: 900

ISSN: 0945-6317

eISSN: 1432-2307

DOI: https://doi.org/10.1007/s00428-024-03775-y

Web address : https://link.springer.com/article/10.1007/s00428-024-03775-y

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387372109

Abstract

Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.

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s00428-024-03775-y.pdf

Funding information in the publication:
Open access publishing supported by the National Technical Library in Prague. This study was supported by a study grant from the Cooperation Program, research area SURG (Alena Skálová, Martina Bradová), the project National Institute for Cancer Research—NICR (Programme EXCELES, ID project no. LX22NPO5102)—funded by the European Union—Next Generation EU (Alena Skálová, Martina Bradová), the Turku University Hospital Fund, the Maritza and Reino Salonen Foundation, and the Finnish Cancer Society, Finland (Ilmo Leivo).