A1 Refereed original research article in a scientific journal
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Authors: Rausio Heidi, Cervera Alejandra, Heuser Vanina D., West Gun, Oikkonen Jaana, Pianfetti Elena, Lovino Marta, Ficarra Elisa, Taimen Pekka, Hynninen Johanna, Lehtonen Rainer, Hautaniemi Sampsa, Carpén Olli, Huhtinen Kaisa
Publisher: Elsevier
Publication year: 2024
Journal: Neoplasia
Journal name in source: Neoplasia
Article number: 100987
Volume: 51
ISSN: 1476-5586
eISSN: 1476-5586
DOI: https://doi.org/10.1016/j.neo.2024.100987(external)
Web address : https://doi.org/10.1016/j.neo.2024.100987(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387295157(external)
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to the fusion protein, CIN85, a key regulator of PI3K-AKT-mTOR signaling. Our data suggest that the fusion-driven structure formation induces a previously unrecognized cell survival and resistance mechanism, which depends on ERK1/2-activation.
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