A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Vimentin cage – A double-edged sword in host anti-infection defense
Tekijät: Zhao Shuangshuang, Miao Chenglin, Gao Xuedi, Li Zhifang, Eriksson John E., Jiu Yaming
Kustantaja: Elsevier Ltd
Julkaisuvuosi: 2024
Journal: Current Opinion in Cell Biology
Tietokannassa oleva lehden nimi: Current Opinion in Cell Biology
Artikkelin numero: 102317
Vuosikerta: 86
ISSN: 0955-0674
eISSN: 1879-0410
DOI: https://doi.org/10.1016/j.ceb.2023.102317
Verkko-osoite: https://doi.org/10.1016/j.ceb.2023.102317
Tiivistelmä
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases. These consistent structural alterations in vimentin, induced by a range of viruses and bacteria, highlight the vimentin cage's crucial role. Pathogen-specific factors add complexity to this interaction. In this review, we provide a thorough overview of the functions and mechanisms of the vimentin cage and speculate on vimentin's potential as a novel target for anti-pathogen strategies. © 2023 Elsevier Ltd
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases. These consistent structural alterations in vimentin, induced by a range of viruses and bacteria, highlight the vimentin cage's crucial role. Pathogen-specific factors add complexity to this interaction. In this review, we provide a thorough overview of the functions and mechanisms of the vimentin cage and speculate on vimentin's potential as a novel target for anti-pathogen strategies. © 2023 Elsevier Ltd
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