A2 Refereed review article in a scientific journal
Vimentin cage – A double-edged sword in host anti-infection defense
Authors: Zhao Shuangshuang, Miao Chenglin, Gao Xuedi, Li Zhifang, Eriksson John E., Jiu Yaming
Publisher: Elsevier Ltd
Publication year: 2024
Journal: Current Opinion in Cell Biology
Journal name in source: Current Opinion in Cell Biology
Article number: 102317
Volume: 86
ISSN: 0955-0674
eISSN: 1879-0410
DOI: https://doi.org/10.1016/j.ceb.2023.102317
Web address : https://doi.org/10.1016/j.ceb.2023.102317
Abstract
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases. These consistent structural alterations in vimentin, induced by a range of viruses and bacteria, highlight the vimentin cage's crucial role. Pathogen-specific factors add complexity to this interaction. In this review, we provide a thorough overview of the functions and mechanisms of the vimentin cage and speculate on vimentin's potential as a novel target for anti-pathogen strategies. © 2023 Elsevier Ltd
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases. These consistent structural alterations in vimentin, induced by a range of viruses and bacteria, highlight the vimentin cage's crucial role. Pathogen-specific factors add complexity to this interaction. In this review, we provide a thorough overview of the functions and mechanisms of the vimentin cage and speculate on vimentin's potential as a novel target for anti-pathogen strategies. © 2023 Elsevier Ltd
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