Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)

Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review




Julkaisun tekijätJha Shambhavi, Thasma Loganathbabu Vasanth Kanth, Kumaran Kasinathan, Krishnasamy Gobinath, Aruljothi Kandasamy Nagarajan

Julkaisuvuosi2024

JournalNon-coding RNA

Tietokannassa oleva lehden nimiNon-coding RNA

Lehden akronyymiNoncoding RNA

Volyymi10

Julkaisunumero1

ISSN2311-553X

eISSN2311-553X

DOIhttp://dx.doi.org/10.3390/ncrna10010003

Verkko-osoitehttps://www.mdpi.com/2311-553X/10/1/3

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/381351593


Tiivistelmä
Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation. Notable lncRNAs like Fendrr, Trpm3, and Scarb2 have demonstrated therapeutic potential in HF cases. Additionally, utilizing lncRNAs to forecast survival rates in HF patients and distinguish various cardiac remodeling conditions holds great promise, offering significant benefits in managing cardiovascular disease and addressing its far-reaching societal and economic impacts. This underscores the pivotal role of lncRNAs in the context of HF research and treatment.

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Last updated on 2024-27-02 at 13:17