A2 Refereed review article in a scientific journal
Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review
Authors: Jha Shambhavi, Thasma Loganathbabu Vasanth Kanth, Kumaran Kasinathan, Krishnasamy Gobinath, Aruljothi Kandasamy Nagarajan
Publication year: 2024
Journal: Non-coding RNA
Journal name in source: Non-coding RNA
Journal acronym: Noncoding RNA
Volume: 10
Issue: 1
ISSN: 2311-553X
eISSN: 2311-553X
DOI: https://doi.org/10.3390/ncrna10010003
Web address : https://www.mdpi.com/2311-553X/10/1/3
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/381351593
Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation. Notable lncRNAs like Fendrr, Trpm3, and Scarb2 have demonstrated therapeutic potential in HF cases. Additionally, utilizing lncRNAs to forecast survival rates in HF patients and distinguish various cardiac remodeling conditions holds great promise, offering significant benefits in managing cardiovascular disease and addressing its far-reaching societal and economic impacts. This underscores the pivotal role of lncRNAs in the context of HF research and treatment.
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