A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
In vivo imaging of the cannabinoid CB1 receptor with positron emission tomography
Tekijät: J Hirvonen
Kustantaja: John Wiley & Sons, Inc,
Julkaisuvuosi: 2015
Journal: Clinical Pharmacology and Therapeutics
Lehden akronyymi: Clin Pharmacol Ther
Vuosikerta: 97
Numero: 6
Aloitussivu: 565
Lopetussivu: 567
Sivujen määrä: 3
ISSN: 0009-9236
DOI: https://doi.org/10.1002/cpt.116
Verkko-osoite: http://onlinelibrary.wiley.com/doi/10.1002/cpt.116/pdf
Positron emission tomography (PET) can visualize and quantify receptors and other targets in the living human brain, and recent progress in radioligand development has enabled measurement of cannabinoid type-1 (CB1 ) receptors. Cannabinoid CB1 receptors have been implicated in multiple human diseases, such as obesity, mood disorders, and addiction. First in vivo human studies have shown distinctive spatial and temporal alterations in cannabinoid CB1 receptor binding in addictive disorders.
