A1 Refereed original research article in a scientific journal
In vivo imaging of the cannabinoid CB1 receptor with positron emission tomography
Authors: J Hirvonen
Publisher: John Wiley & Sons, Inc,
Publication year: 2015
Journal: Clinical Pharmacology and Therapeutics
Journal acronym: Clin Pharmacol Ther
Volume: 97
Issue: 6
First page : 565
Last page: 567
Number of pages: 3
ISSN: 0009-9236
DOI: https://doi.org/10.1002/cpt.116
Web address : http://onlinelibrary.wiley.com/doi/10.1002/cpt.116/pdf
Positron emission tomography (PET) can visualize and quantify receptors and other targets in the living human brain, and recent progress in radioligand development has enabled measurement of cannabinoid type-1 (CB1 ) receptors. Cannabinoid CB1 receptors have been implicated in multiple human diseases, such as obesity, mood disorders, and addiction. First in vivo human studies have shown distinctive spatial and temporal alterations in cannabinoid CB1 receptor binding in addictive disorders.