A1 Refereed original research article in a scientific journal

In vivo imaging of the cannabinoid CB1 receptor with positron emission tomography




AuthorsJ Hirvonen

PublisherJohn Wiley & Sons, Inc,

Publication year2015

JournalClinical Pharmacology and Therapeutics

Journal acronymClin Pharmacol Ther

Volume97

Issue6

First page 565

Last page567

Number of pages3

ISSN0009-9236

DOIhttps://doi.org/10.1002/cpt.116

Web address http://onlinelibrary.wiley.com/doi/10.1002/cpt.116/pdf


Abstract

Positron emission tomography (PET) can visualize and quantify receptors and other targets in the living human brain, and recent progress in radioligand development has enabled measurement of cannabinoid type-1 (CB1 ) receptors. Cannabinoid CB1 receptors have been implicated in multiple human diseases, such as obesity, mood disorders, and addiction. First in vivo human studies have shown distinctive spatial and temporal alterations in cannabinoid CB1 receptor binding in addictive disorders.

 




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