Inflammation and Increased Myxovirus Resistance Protein A Expression in Thyroid Tissue in the Early Stages of Hashimoto's Thyroiditis

: Hammerstad SS, Jahnsen FL, Tauriainen S, Hyoty H, Paulsen T, Norheim I, Dahl-Jorgensen K

Publisher: MARY ANN LIEBERT INC

: 2013

: Thyroid

: THYROID

: 3

: 23

: 3

: 334

: 341

: 8

: 1050-7256

DOI: https://doi.org/10.1089/thy.2012.0264

Conclusion: The inflammatory reaction in the thyroid gland is a very early event in the pathogenesis of HT. The increased expression of MxA in the inflamed tissue suggests that type I IFN plays a role in disease development. Whether this is virus-dependent needs to be explored in further studies.