A1 Refereed original research article in a scientific journal
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
Authors: Jarvela JT, Lopez-Picon FR, Plysjuk A, Ruohonen S, Holopainen IE
Publisher: BIOMED CENTRAL LTD
Publication year: 2011
Journal: Journal of Neuroinflammation
Journal name in source: JOURNAL OF NEUROINFLAMMATION
Journal acronym: J NEUROINFLAMM
Article number: ARTN 29
Volume: 8
Number of pages: 12
ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-8-29(external)
Abstract
Conclusion: Our results suggest that SE provokes an age-specific cytokine expression in the acute phase, and age-specific glial cell activation in the subacute phase as verified now in the postnatal rat hippocampus. In the juvenile hippocampus, transient increases in cytokine mRNA expression after SE, in contrast to prolonged glial reactivity and region-specific microglial activity after SE, suggest that the inflammatory response is changed from a fulminant and general initial phase to a more moderate and specific subacute response.
Conclusion: Our results suggest that SE provokes an age-specific cytokine expression in the acute phase, and age-specific glial cell activation in the subacute phase as verified now in the postnatal rat hippocampus. In the juvenile hippocampus, transient increases in cytokine mRNA expression after SE, in contrast to prolonged glial reactivity and region-specific microglial activity after SE, suggest that the inflammatory response is changed from a fulminant and general initial phase to a more moderate and specific subacute response.
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