A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
Tekijät: Jarvela JT, Lopez-Picon FR, Plysjuk A, Ruohonen S, Holopainen IE
Kustantaja: BIOMED CENTRAL LTD
Julkaisuvuosi: 2011
Journal: Journal of Neuroinflammation
Tietokannassa oleva lehden nimi: JOURNAL OF NEUROINFLAMMATION
Lehden akronyymi: J NEUROINFLAMM
Artikkelin numero: ARTN 29
Vuosikerta: 8
Sivujen määrä: 12
ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-8-29
Tiivistelmä
Conclusion: Our results suggest that SE provokes an age-specific cytokine expression in the acute phase, and age-specific glial cell activation in the subacute phase as verified now in the postnatal rat hippocampus. In the juvenile hippocampus, transient increases in cytokine mRNA expression after SE, in contrast to prolonged glial reactivity and region-specific microglial activity after SE, suggest that the inflammatory response is changed from a fulminant and general initial phase to a more moderate and specific subacute response.
Conclusion: Our results suggest that SE provokes an age-specific cytokine expression in the acute phase, and age-specific glial cell activation in the subacute phase as verified now in the postnatal rat hippocampus. In the juvenile hippocampus, transient increases in cytokine mRNA expression after SE, in contrast to prolonged glial reactivity and region-specific microglial activity after SE, suggest that the inflammatory response is changed from a fulminant and general initial phase to a more moderate and specific subacute response.
Turun yliopiston Tutkimustietojärjestelmän portaali