Effects of tolterodine on afferent neurotransmission in normal and resiniferatoxin treated conscious rats



: Hedlund P, Streng T, Lee T, Andersson KE

Publisher: ELSEVIER SCIENCE INC

: 2007

Journal of Urology

JOURNAL OF UROLOGY

: J UROLOGY

: 178

: 1

: 326

: 331

: 6

: 0022-5347

DOI: https://doi.org/10.1016/j.juro.2007.03.006


Conclusions: Tolterodine increased the micturition interval and bladder capacity in controls and in resiniferatoxin treated animals, suggesting that these effects were exerted independently of resiniferatoxin sensitive afferents. Tolterodine did not decrease the contractile effects of apomorphine at the doses used, suggesting that the drug had no effect on efferent neurotransmission during voiding.



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