A1 Refereed original research article in a scientific journal
Effects of tolterodine on afferent neurotransmission in normal and resiniferatoxin treated conscious rats
Authors: Hedlund P, Streng T, Lee T, Andersson KE
Publisher: ELSEVIER SCIENCE INC
Publication year: 2007
Journal:Journal of Urology
Journal name in sourceJOURNAL OF UROLOGY
Journal acronym: J UROLOGY
Volume: 178
Issue: 1
First page : 326
Last page: 331
Number of pages: 6
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2007.03.006
Abstract
Conclusions: Tolterodine increased the micturition interval and bladder capacity in controls and in resiniferatoxin treated animals, suggesting that these effects were exerted independently of resiniferatoxin sensitive afferents. Tolterodine did not decrease the contractile effects of apomorphine at the doses used, suggesting that the drug had no effect on efferent neurotransmission during voiding.
Conclusions: Tolterodine increased the micturition interval and bladder capacity in controls and in resiniferatoxin treated animals, suggesting that these effects were exerted independently of resiniferatoxin sensitive afferents. Tolterodine did not decrease the contractile effects of apomorphine at the doses used, suggesting that the drug had no effect on efferent neurotransmission during voiding.
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