Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats



: Streng T, Christoph T, Andersson KE

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2004

Journal of Urology

JOURNAL OF UROLOGY

: J UROLOGY

: 172

: 5

: 2054

: 2058

: 5

: 0022-5347

DOI: https://doi.org/10.1097/01.ju.0000138155.33749.f4


Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.



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