A1 Refereed original research article in a scientific journal
Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats
Authors: Streng T, Christoph T, Andersson KE
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2004
Journal:: Journal of Urology
Journal name in source: JOURNAL OF UROLOGY
Journal acronym: J UROLOGY
Volume: 172
Issue: 5
First page : 2054
Last page: 2058
Number of pages: 5
ISSN: 0022-5347
DOI: https://doi.org/10.1097/01.ju.0000138155.33749.f4
Abstract
Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.
Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.
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