A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats
Tekijät: Streng T, Christoph T, Andersson KE
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2004
Lehti:: Journal of Urology
Tietokannassa oleva lehden nimi: JOURNAL OF UROLOGY
Lehden akronyymi: J UROLOGY
Vuosikerta: 172
Numero: 5
Aloitussivu: 2054
Lopetussivu: 2058
Sivujen määrä: 5
ISSN: 0022-5347
DOI: https://doi.org/10.1097/01.ju.0000138155.33749.f4
Tiivistelmä
Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.
Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.
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