Voriconazole and fluconazole increase the exposure to oral diazepam



: Saari TI, Laine K, Bertilsson L, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER

: 2007

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 63

: 10

: 941

: 949

: 9

: 0031-6970

DOI: https://doi.org/10.1007/s00228-007-0350-0


Conclusion Both voriconazole and fluconazole considerably increase the exposure to diazepam. Recurrent administration of diazepam increases the risk of clinically significant interactions during voriconazole or fluconazole treatment, because the elimination of diazepam is impaired significantly.

Last updated on 2024-26-11 at 10:48