A1 Refereed original research article in a scientific journal

Voriconazole and fluconazole increase the exposure to oral diazepam



Authors: Saari TI, Laine K, Bertilsson L, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER

Publication year: 2007

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Volume: 63

Issue: 10

First page : 941

Last page: 949

Number of pages: 9

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-007-0350-0


Abstract
Conclusion Both voriconazole and fluconazole considerably increase the exposure to diazepam. Recurrent administration of diazepam increases the risk of clinically significant interactions during voriconazole or fluconazole treatment, because the elimination of diazepam is impaired significantly.

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Last updated on 2024-26-11 at 10:48