A facile solid-phase synthesis of 5,1 ',5 '-trisubstituted 2,4 '-biimidazoles

: Karskela T, Lonnberg H

: -

: 2008

Collection Symposium Series

: Chemistry of Nucleic Acid Components (Symposium)

CHEMISTRY OF NUCLEIC ACID COMPONENTS

: COLL SYMPOS SERIES

: 10

: 372

: 373

: 2

: 978-80-86241-29-6

A method for synthesis of libraries of 5,1',5'-trisubstituted 2,4'-biimidazoles on a solid support was developed. A trivalent scaffold, 2-(5'-amino-5-formyl-1H,1'H-2,4'-biimidazol-1'-yl)acetic acid, is first prepared by a two step synthesis in solution. The product is then coupled to an amino acid loaded Wang resin, further derivatized in two steps and released from the resin.

Chemical sciences