B3 Vertaisarvioimaton artikkeli konferenssijulkaisussa
A facile solid-phase synthesis of 5,1 ',5 '-trisubstituted 2,4 '-biimidazoles
Tekijät: Karskela T, Lonnberg H
Toimittaja: -
Julkaisuvuosi: 2008
Lehti:: Collection Symposium Series
Kokoomateoksen nimi: Chemistry of Nucleic Acid Components (Symposium)
Tietokannassa oleva lehden nimi: CHEMISTRY OF NUCLEIC ACID COMPONENTS
Lehden akronyymi: COLL SYMPOS SERIES
Vuosikerta: 10
Aloitussivu: 372
Lopetussivu: 373
Sivujen määrä: 2
ISBN: 978-80-86241-29-6
Tiivistelmä
A method for synthesis of libraries of 5,1',5'-trisubstituted 2,4'-biimidazoles on a solid support was developed. A trivalent scaffold, 2-(5'-amino-5-formyl-1H,1'H-2,4'-biimidazol-1'-yl)acetic acid, is first prepared by a two step synthesis in solution. The product is then coupled to an amino acid loaded Wang resin, further derivatized in two steps and released from the resin.
A method for synthesis of libraries of 5,1',5'-trisubstituted 2,4'-biimidazoles on a solid support was developed. A trivalent scaffold, 2-(5'-amino-5-formyl-1H,1'H-2,4'-biimidazol-1'-yl)acetic acid, is first prepared by a two step synthesis in solution. The product is then coupled to an amino acid loaded Wang resin, further derivatized in two steps and released from the resin.
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