B3 Non-refereed article in a conference publication
A facile solid-phase synthesis of 5,1 ',5 '-trisubstituted 2,4 '-biimidazoles
Authors: Karskela T, Lonnberg H
Editors: -
Publication year: 2008
Journal:: Collection Symposium Series
Book title : Chemistry of Nucleic Acid Components (Symposium)
Journal name in source: CHEMISTRY OF NUCLEIC ACID COMPONENTS
Journal acronym: COLL SYMPOS SERIES
Volume: 10
First page : 372
Last page: 373
Number of pages: 2
ISBN: 978-80-86241-29-6
Abstract
A method for synthesis of libraries of 5,1',5'-trisubstituted 2,4'-biimidazoles on a solid support was developed. A trivalent scaffold, 2-(5'-amino-5-formyl-1H,1'H-2,4'-biimidazol-1'-yl)acetic acid, is first prepared by a two step synthesis in solution. The product is then coupled to an amino acid loaded Wang resin, further derivatized in two steps and released from the resin.
A method for synthesis of libraries of 5,1',5'-trisubstituted 2,4'-biimidazoles on a solid support was developed. A trivalent scaffold, 2-(5'-amino-5-formyl-1H,1'H-2,4'-biimidazol-1'-yl)acetic acid, is first prepared by a two step synthesis in solution. The product is then coupled to an amino acid loaded Wang resin, further derivatized in two steps and released from the resin.
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