Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations



: Palkola NV, Pakkanen SH, Kantele JM, Pakarinen L, Puohiniemi R, Kantele A

Publisher: OXFORD UNIV PRESS INC

: 2015

: Journal of Infectious Diseases

: JOURNAL OF INFECTIOUS DISEASES

: J INFECT DIS

: 212

: 8

: 1279

: 1287

: 9

: 0022-1899

DOI: https://doi.org/10.1093/infdis/jiv208


Conclusions. The homing receptor profile in patients with pneumonia was unique yet it was closer to that in PCV recipients than in PPV recipients. These data suggest greater mucosal localization for immune response in natural infection, which is clinically interesting, especially considering the shortcomings of vaccines in protecting against noninvasive pneumonia.




Last updated on 2024-26-11 at 19:02