Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations - UTU Research Portal

A1 Refereed original research article in a scientific journal

Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations

Authors: Palkola NV, Pakkanen SH, Kantele JM, Pakarinen L, Puohiniemi R, Kantele A

Publisher: OXFORD UNIV PRESS INC

Publication year: 2015

Journal: Journal of Infectious Diseases

Journal name in source: JOURNAL OF INFECTIOUS DISEASES

Journal acronym: J INFECT DIS

Volume: 212

Issue: 8

First page : 1279

Last page: 1287

Number of pages: 9

ISSN: 0022-1899

DOI: https://doi.org/10.1093/infdis/jiv208

Abstract

Conclusions. The homing receptor profile in patients with pneumonia was unique yet it was closer to that in PCV recipients than in PPV recipients. These data suggest greater mucosal localization for immune response in natural infection, which is clinically interesting, especially considering the shortcomings of vaccines in protecting against noninvasive pneumonia.