Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations - UTU Tutkimustietojärjestelmä

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Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations

Tekijät: Palkola NV, Pakkanen SH, Kantele JM, Pakarinen L, Puohiniemi R, Kantele A

Kustantaja: OXFORD UNIV PRESS INC

Julkaisuvuosi: 2015

Journal: Journal of Infectious Diseases

Tietokannassa oleva lehden nimi: JOURNAL OF INFECTIOUS DISEASES

Lehden akronyymi: J INFECT DIS

Vuosikerta: 212

Numero: 8

Aloitussivu: 1279

Lopetussivu: 1287

Sivujen määrä: 9

ISSN: 0022-1899

DOI: https://doi.org/10.1093/infdis/jiv208

Tiivistelmä

Conclusions. The homing receptor profile in patients with pneumonia was unique yet it was closer to that in PCV recipients than in PPV recipients. These data suggest greater mucosal localization for immune response in natural infection, which is clinically interesting, especially considering the shortcomings of vaccines in protecting against noninvasive pneumonia.