Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus

: Jarvela JT, Lopez-Picon FR, Holopainen IE

Publisher: BLACKWELL PUBLISHING

: 2008

: Epilepsia

: EPILEPSIA

: 49

: 5

: 832

: 841

: 10

: 0013-9580

DOI: https://doi.org/10.1111/j.1528-1167.2007.01454.x

Discussion: Our results suggest that SE provokes age-specific effects on COX-2 expression. This together with the activation of putative inflammatory processes may contribute to neuronal cell death in the hippocampus of postnatal rats, whereas caspase-dependent apoptosis seems not to be involved in the death process.