A1 Refereed original research article in a scientific journal

Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus



Authors: Jarvela JT, Lopez-Picon FR, Holopainen IE

Publisher: BLACKWELL PUBLISHING

Publication year: 2008

Journal: Epilepsia

Journal name in source: EPILEPSIA

Journal acronym: EPILEPSIA

Volume: 49

Issue: 5

First page : 832

Last page: 841

Number of pages: 10

ISSN: 0013-9580

DOI: https://doi.org/10.1111/j.1528-1167.2007.01454.x


Abstract
Discussion: Our results suggest that SE provokes age-specific effects on COX-2 expression. This together with the activation of putative inflammatory processes may contribute to neuronal cell death in the hippocampus of postnatal rats, whereas caspase-dependent apoptosis seems not to be involved in the death process.



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