Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl



: Saari TI, Laine K, Neuvonen M, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER

: 2008

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 64

: 1

: 25

: 30

: 6

: 0031-6970

DOI: https://doi.org/10.1007/s00228-007-0398-x


Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.

Last updated on 2024-26-11 at 18:17