A1 Refereed original research article in a scientific journal
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl
Authors: Saari TI, Laine K, Neuvonen M, Neuvonen PJ, Olkkola KT
Publisher: SPRINGER
Publication year: 2008
Journal: European Journal of Clinical Pharmacology
Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Journal acronym: EUR J CLIN PHARMACOL
Volume: 64
Issue: 1
First page : 25
Last page: 30
Number of pages: 6
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-007-0398-x
Abstract
Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
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