A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl
Tekijät: Saari TI, Laine K, Neuvonen M, Neuvonen PJ, Olkkola KT
Kustantaja: SPRINGER
Julkaisuvuosi: 2008
Journal: European Journal of Clinical Pharmacology
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Lehden akronyymi: EUR J CLIN PHARMACOL
Vuosikerta: 64
Numero: 1
Aloitussivu: 25
Lopetussivu: 30
Sivujen määrä: 6
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-007-0398-x
Tiivistelmä
Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
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