A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study

: Jylhava J, Lyytikainen LP, Kahonen M, Hutri-Kahonen N, Kettunen J, Viikari J, Raitakari OT, Lehtimaki T, Hurme M

Publisher: PUBLIC LIBRARY SCIENCE

: 2012

: PLoS ONE

: PLOS ONE

: ARTN e35426

: 4

: 7

: 4

: e35426

: 7

: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0035426

Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.