A1 Refereed original research article in a scientific journal

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study




AuthorsJylhava J, Lyytikainen LP, Kahonen M, Hutri-Kahonen N, Kettunen J, Viikari J, Raitakari OT, Lehtimaki T, Hurme M

PublisherPUBLIC LIBRARY SCIENCE

Publication year2012

JournalPLoS ONE

Journal name in sourcePLOS ONE

Journal acronymPLOS ONE

Article numberARTN e35426

Number in series4

Volume7

Issue4

First page e35426

Number of pages7

ISSN1932-6203

DOIhttps://doi.org/10.1371/journal.pone.0035426(external)


Abstract
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.



Last updated on 2024-26-11 at 17:32