A1 Refereed original research article in a scientific journal
A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
Authors: Jylhava J, Lyytikainen LP, Kahonen M, Hutri-Kahonen N, Kettunen J, Viikari J, Raitakari OT, Lehtimaki T, Hurme M
Publisher: PUBLIC LIBRARY SCIENCE
Publication year: 2012
Journal: PLoS ONE
Journal name in source: PLOS ONE
Journal acronym: PLOS ONE
Article number: ARTN e35426
Number in series: 4
Volume: 7
Issue: 4
First page : e35426
Number of pages: 7
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0035426(external)
Abstract
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.