A1 Refereed original research article in a scientific journal

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study



Authors: Jylhava J, Lyytikainen LP, Kahonen M, Hutri-Kahonen N, Kettunen J, Viikari J, Raitakari OT, Lehtimaki T, Hurme M

Publisher: PUBLIC LIBRARY SCIENCE

Publication year: 2012

Journal: PLoS ONE

Journal name in source: PLOS ONE

Journal acronym: PLOS ONE

Article number: ARTN e35426

Number in series: 4

Volume: 7

Issue: 4

First page : e35426

Number of pages: 7

ISSN: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0035426(external)


Abstract
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.



Last updated on 2024-26-11 at 17:32