A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
Tekijät: Jylhava J, Lyytikainen LP, Kahonen M, Hutri-Kahonen N, Kettunen J, Viikari J, Raitakari OT, Lehtimaki T, Hurme M
Kustantaja: PUBLIC LIBRARY SCIENCE
Julkaisuvuosi: 2012
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: PLOS ONE
Lehden akronyymi: PLOS ONE
Artikkelin numero: ARTN e35426
Numero sarjassa: 4
Vuosikerta: 7
Numero: 4
Aloitussivu: e35426
Sivujen määrä: 7
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0035426
Tiivistelmä
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.
Conclusion: The UGT1A1 enzyme catalyses the detoxification of several drugs and the turnover of many xenobiotic and endogenous compounds by glucuronidating its substrates. These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations.
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