Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues



: Hu WM, Xu J, Sinkkonen J, Wu J

Publisher: BENTHAM SCIENCE PUBL LTD

: 2010

 Mini-Reviews in Medicinal Chemistry

: MINI-REVIEWS IN MEDICINAL CHEMISTRY

: MINI-REV MED CHEM

: 1

: 10

: 1

: 51

: 61

: 11

: 1389-5575

DOI: https://doi.org/10.2174/138955710791112541


Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.



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