A1 Refereed original research article in a scientific journal
Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues
Authors: Hu WM, Xu J, Sinkkonen J, Wu J
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2010
Journal: Mini-Reviews in Medicinal Chemistry
Journal name in source: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Journal acronym: MINI-REV MED CHEM
Number in series: 1
Volume: 10
Issue: 1
First page : 51
Last page: 61
Number of pages: 11
ISSN: 1389-5575
DOI: https://doi.org/10.2174/138955710791112541
Abstract
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
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