A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues
Tekijät: Hu WM, Xu J, Sinkkonen J, Wu J
Kustantaja: BENTHAM SCIENCE PUBL LTD
Julkaisuvuosi: 2010
Lehti: Mini-Reviews in Medicinal Chemistry
Tietokannassa oleva lehden nimi: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Lehden akronyymi: MINI-REV MED CHEM
Numero sarjassa: 1
Vuosikerta: 10
Numero: 1
Aloitussivu: 51
Lopetussivu: 61
Sivujen määrä: 11
ISSN: 1389-5575
DOI: https://doi.org/10.2174/138955710791112541
Tiivistelmä
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
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