Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms



: Lonnberg T, Ora M, Lonnberg H

Publisher: BENTHAM SCIENCE PUBL LTD

: 2010

: Mini-Reviews in Organic Chemistry

: MINI-REVIEWS IN ORGANIC CHEMISTRY

: MINI-REV ORG CHEM

: 1

: 7

: 1

: 33

: 43

: 11

: 1570-193X


Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.



Last updated on 2024-26-11 at 12:08