A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms
Tekijät: Lonnberg T, Ora M, Lonnberg H
Kustantaja: BENTHAM SCIENCE PUBL LTD
Julkaisuvuosi: 2010
Journal: Mini-Reviews in Organic Chemistry
Tietokannassa oleva lehden nimi: MINI-REVIEWS IN ORGANIC CHEMISTRY
Lehden akronyymi: MINI-REV ORG CHEM
Numero sarjassa: 1
Vuosikerta: 7
Numero: 1
Aloitussivu: 33
Lopetussivu: 43
Sivujen määrä: 11
ISSN: 1570-193X
Tiivistelmä
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.
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