A2 Refereed review article in a scientific journal
Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms
Authors: Lonnberg T, Ora M, Lonnberg H
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2010
Journal: Mini-Reviews in Organic Chemistry
Journal name in source: MINI-REVIEWS IN ORGANIC CHEMISTRY
Journal acronym: MINI-REV ORG CHEM
Number in series: 1
Volume: 7
Issue: 1
First page : 33
Last page: 43
Number of pages: 11
ISSN: 1570-193X
Abstract
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.
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