APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury

: Koponen S, Taiminen T, Kairisto V, Portin R, Isoniemi H, Hinkka S, Tenovuo O

: 2004

: Neurology

: 63

: 4

: 749

: 50

: 2

: 0028-3878

: 1526-632X

DOI: https://doi.org/10.1212/01.WNL.0000134603.57107.2F

The authors studied the association between APOE-epsilon4 genotype and axis I and II psychiatric disorders an average of 30 years after traumatic brain injury. Sixty patients were dichotomized into subjects with and without APOE-epsilon4 allele. Dementia and subclinical dementia were significantly more common with the presence of APOE-epsilon4. The occurrence of other psychiatric disorders did not differ between patients with and without APOE-epsilon4 allele.