OPTIMIZATION OF H-2 O-15-CBF METHOD FOR HIGHER SIGNAL-TO-NOISE RATIO



: KANNO I, IIDA H, MIURA S

Publisher: KLUWER ACADEMIC PUBL

: 1991

: Medical progress through technology

: MEDICAL PROGRESS THROUGH TECHNOLOGY

: MED PROG TECHNOL

: 17

: 3-4

: 189

: 192

: 4

: 0047-6552


We described theoretical principle and data analysis for PET study using intravenous (H2O)-O-15 for measurement of cerebral blood flow (CBF) with emphasis on stimulation study for psychophysiological test. In order to improve signal-to-noise (S/N) ratio in CBF images, we optimized the scan procedures and data analysis. We determined optimal scantime of autoradiographic image to provide minimum S/N ratio as to 90 through 120 sec. Increase of full-width at half-maximum (FWHM) of smoothing filter did reduce the image noise (standard deviation, SD) more rapidly than the partial volume effect. Phantom experiment showed a tendency that a larger FWHM provided a higher statistical t-value.



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