A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
OPTIMIZATION OF H-2 O-15-CBF METHOD FOR HIGHER SIGNAL-TO-NOISE RATIO
Tekijät: KANNO I, IIDA H, MIURA S
Kustantaja: KLUWER ACADEMIC PUBL
Julkaisuvuosi: 1991
Journal: Medical progress through technology
Tietokannassa oleva lehden nimi: MEDICAL PROGRESS THROUGH TECHNOLOGY
Lehden akronyymi: MED PROG TECHNOL
Vuosikerta: 17
Numero: 3-4
Aloitussivu: 189
Lopetussivu: 192
Sivujen määrä: 4
ISSN: 0047-6552
Tiivistelmä
We described theoretical principle and data analysis for PET study using intravenous (H2O)-O-15 for measurement of cerebral blood flow (CBF) with emphasis on stimulation study for psychophysiological test. In order to improve signal-to-noise (S/N) ratio in CBF images, we optimized the scan procedures and data analysis. We determined optimal scantime of autoradiographic image to provide minimum S/N ratio as to 90 through 120 sec. Increase of full-width at half-maximum (FWHM) of smoothing filter did reduce the image noise (standard deviation, SD) more rapidly than the partial volume effect. Phantom experiment showed a tendency that a larger FWHM provided a higher statistical t-value.
We described theoretical principle and data analysis for PET study using intravenous (H2O)-O-15 for measurement of cerebral blood flow (CBF) with emphasis on stimulation study for psychophysiological test. In order to improve signal-to-noise (S/N) ratio in CBF images, we optimized the scan procedures and data analysis. We determined optimal scantime of autoradiographic image to provide minimum S/N ratio as to 90 through 120 sec. Increase of full-width at half-maximum (FWHM) of smoothing filter did reduce the image noise (standard deviation, SD) more rapidly than the partial volume effect. Phantom experiment showed a tendency that a larger FWHM provided a higher statistical t-value.
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