Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative

: Koskimaa HM, Paaso A, Welters MJP, Grenman S, Syrjanen K, van der Burg SH, Syrjanen S

Publisher: BIOMED CENTRAL LTD

: 2015

: Journal of Translational Medicine

: JOURNAL OF TRANSLATIONAL MEDICINE

: J TRANSL MED

: ARTN 370

: 13

: 11

: 1479-5876

DOI: https://doi.org/10.1186/s12967-015-0733-4

Conclusions: HPV16-specific CMI is common in young, sexually inexperienced children. This suggests that oral HPV infections occur frequently in children. Our results might also explain the previous findings that half of healthy adults demonstrate HPV-specific CMI irrespective of their partner/sexual status.