Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative - UTU Research Portal

A1 Refereed original research article in a scientific journal

Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative

Authors: Koskimaa HM, Paaso A, Welters MJP, Grenman S, Syrjanen K, van der Burg SH, Syrjanen S

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: Journal of Translational Medicine

Journal name in source: JOURNAL OF TRANSLATIONAL MEDICINE

Journal acronym: J TRANSL MED

Article number: ARTN 370

Volume: 13

Number of pages: 11

ISSN: 1479-5876

eISSN: 1479-5876

DOI: https://doi.org/10.1186/s12967-015-0733-4

Abstract

Conclusions: HPV16-specific CMI is common in young, sexually inexperienced children. This suggests that oral HPV infections occur frequently in children. Our results might also explain the previous findings that half of healthy adults demonstrate HPV-specific CMI irrespective of their partner/sexual status.