Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative

Tekijät: Koskimaa HM, Paaso A, Welters MJP, Grenman S, Syrjanen K, van der Burg SH, Syrjanen S

Kustantaja: BIOMED CENTRAL LTD

Julkaisuvuosi: 2015

Journal: Journal of Translational Medicine

Tietokannassa oleva lehden nimi: JOURNAL OF TRANSLATIONAL MEDICINE

Lehden akronyymi: J TRANSL MED

Artikkelin numero: ARTN 370

Vuosikerta: 13

Sivujen määrä: 11

ISSN: 1479-5876

eISSN: 1479-5876

DOI: https://doi.org/10.1186/s12967-015-0733-4

Tiivistelmä

Conclusions: HPV16-specific CMI is common in young, sexually inexperienced children. This suggests that oral HPV infections occur frequently in children. Our results might also explain the previous findings that half of healthy adults demonstrate HPV-specific CMI irrespective of their partner/sexual status.