Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET

: Edison P, Carter SF, Rinne JO, Gelosa G, Herholz K, Nordberg A, Brooks DJ, Hinz R

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

: 2013

: NeuroImage

: NEUROIMAGE

: 70

: 423

: 433

: 11

: 1053-8119

DOI: https://doi.org/10.1016/j.neuroimage.2012.12.014

Conclusions: Definition of cortical grey matter regions is more accurate when individually segmented MRIs (Route 1) were used rather than a population-based PET template (Route 2). The impact of this difference depends on the grey-to-white matter contrast in the PET images; specifically seen in healthy controls with high white matter and low grey matter uptake. When classifying AD, MCI and control subjects as normal or abnormal using large cortical regions; discordance was found between the MRI and template approach for those few subjects who presented with cortex-to-cerebellum ratios very close to the pre-assigned cut-off. However, posterior cingulate alone demonstrated significant discordance in healthy controls using template based approach. This study, therefore, demonstrates that the use of a [C-11]PIB PET template (Route 2) is adequate for clinical diagnostic purposes, while MRI based analysis (Route 1) remains more appropriate for clinical research. (c) 2012 Elsevier Inc. All rights reserved.