A1 Refereed original research article in a scientific journal
Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
Authors: Edison P, Carter SF, Rinne JO, Gelosa G, Herholz K, Nordberg A, Brooks DJ, Hinz R
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication year: 2013
Journal: NeuroImage
Journal name in source: NEUROIMAGE
Journal acronym: NEUROIMAGE
Volume: 70
First page : 423
Last page: 433
Number of pages: 11
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2012.12.014
Abstract
Conclusions: Definition of cortical grey matter regions is more accurate when individually segmented MRIs (Route 1) were used rather than a population-based PET template (Route 2). The impact of this difference depends on the grey-to-white matter contrast in the PET images; specifically seen in healthy controls with high white matter and low grey matter uptake. When classifying AD, MCI and control subjects as normal or abnormal using large cortical regions; discordance was found between the MRI and template approach for those few subjects who presented with cortex-to-cerebellum ratios very close to the pre-assigned cut-off. However, posterior cingulate alone demonstrated significant discordance in healthy controls using template based approach. This study, therefore, demonstrates that the use of a [C-11]PIB PET template (Route 2) is adequate for clinical diagnostic purposes, while MRI based analysis (Route 1) remains more appropriate for clinical research. (c) 2012 Elsevier Inc. All rights reserved.
Conclusions: Definition of cortical grey matter regions is more accurate when individually segmented MRIs (Route 1) were used rather than a population-based PET template (Route 2). The impact of this difference depends on the grey-to-white matter contrast in the PET images; specifically seen in healthy controls with high white matter and low grey matter uptake. When classifying AD, MCI and control subjects as normal or abnormal using large cortical regions; discordance was found between the MRI and template approach for those few subjects who presented with cortex-to-cerebellum ratios very close to the pre-assigned cut-off. However, posterior cingulate alone demonstrated significant discordance in healthy controls using template based approach. This study, therefore, demonstrates that the use of a [C-11]PIB PET template (Route 2) is adequate for clinical diagnostic purposes, while MRI based analysis (Route 1) remains more appropriate for clinical research. (c) 2012 Elsevier Inc. All rights reserved.
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