A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
Tekijät: Edison P, Carter SF, Rinne JO, Gelosa G, Herholz K, Nordberg A, Brooks DJ, Hinz R
Kustantaja: ACADEMIC PRESS INC ELSEVIER SCIENCE
Julkaisuvuosi: 2013
Journal: NeuroImage
Tietokannassa oleva lehden nimi: NEUROIMAGE
Lehden akronyymi: NEUROIMAGE
Vuosikerta: 70
Aloitussivu: 423
Lopetussivu: 433
Sivujen määrä: 11
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2012.12.014
Tiivistelmä
Conclusions: Definition of cortical grey matter regions is more accurate when individually segmented MRIs (Route 1) were used rather than a population-based PET template (Route 2). The impact of this difference depends on the grey-to-white matter contrast in the PET images; specifically seen in healthy controls with high white matter and low grey matter uptake. When classifying AD, MCI and control subjects as normal or abnormal using large cortical regions; discordance was found between the MRI and template approach for those few subjects who presented with cortex-to-cerebellum ratios very close to the pre-assigned cut-off. However, posterior cingulate alone demonstrated significant discordance in healthy controls using template based approach. This study, therefore, demonstrates that the use of a [C-11]PIB PET template (Route 2) is adequate for clinical diagnostic purposes, while MRI based analysis (Route 1) remains more appropriate for clinical research. (c) 2012 Elsevier Inc. All rights reserved.
Conclusions: Definition of cortical grey matter regions is more accurate when individually segmented MRIs (Route 1) were used rather than a population-based PET template (Route 2). The impact of this difference depends on the grey-to-white matter contrast in the PET images; specifically seen in healthy controls with high white matter and low grey matter uptake. When classifying AD, MCI and control subjects as normal or abnormal using large cortical regions; discordance was found between the MRI and template approach for those few subjects who presented with cortex-to-cerebellum ratios very close to the pre-assigned cut-off. However, posterior cingulate alone demonstrated significant discordance in healthy controls using template based approach. This study, therefore, demonstrates that the use of a [C-11]PIB PET template (Route 2) is adequate for clinical diagnostic purposes, while MRI based analysis (Route 1) remains more appropriate for clinical research. (c) 2012 Elsevier Inc. All rights reserved.
Turun yliopiston Tutkimustietojärjestelmän portaali