A1 Refereed original research article in a scientific journal
Post-target produced [18F]F2 in the production of PET radiopharmaceuticals.
Authors: Forsback S, Solin O
Publisher: De Gruyter
Publication year: 2015
Journal: Radiochimica Acta
Journal acronym: Radiochim acta
Volume: 103
Issue: 3
First page : 219
Last page: 226
Number of pages: 8
ISSN: 0033-8230
DOI: https://doi.org/10.1515/ract-2014-2334
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/3433612
Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced [F-18]F-2 has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these radiopharmaceuticals, namely [F-18]FDOPA, [F-18]CFT, [F-18]EF5 and [F-18]FBPA.
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