A1 Refereed original research article in a scientific journal

Post-target produced [18F]F2 in the production of PET radiopharmaceuticals.




AuthorsForsback S, Solin O

PublisherDe Gruyter

Publication year2015

JournalRadiochimica Acta

Journal acronymRadiochim acta

Volume103

Issue3

First page 219

Last page226

Number of pages8

ISSN0033-8230

DOIhttps://doi.org/10.1515/ract-2014-2334

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/3433612


Abstract

Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced [F-18]F-2 has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these radiopharmaceuticals, namely [F-18]FDOPA, [F-18]CFT, [F-18]EF5 and [F-18]FBPA.


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