Bifidobacterium and Lactobacillus DNA in the human placenta



: Satokari R, Grönroos T, Laitinen K, Salminen S, Isolauri E

Publisher: WILEY-BLACKWELL PUBLISHING, INC

: 2009

: Letters in Applied Microbiology

: LETTERS IN APPLIED MICROBIOLOGY

: LETT APPL MICROBIOL

: 48

: 1

: 8

: 12

: 5

: 0266-8254

DOI: https://doi.org/10.1111/j.1472-765X.2008.02475.x


Bacterial DNA contains unmethylated CpG oligodeoxynucleotide motifs which induce immune effects. Specific CpG motifs activate Toll-like receptor 9 and subsequently trigger Th-1-type immune responses. Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered.



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